Gain of function mutations in p53

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Martin Scheffner, Bruce A. Werness, Jon M. Huibregtse et al. · Cell · 1990 · 4K citations

Human Papillomavirus Vaccines, Medicine, Pathology +10

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

Jamil Momand, Gerard P. Zambetti, David C. Olson et al. · Cell · 1992 · 3.1K citations

Oncogenic Agent, Medicine, Molecular Biology +9

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

Bruce A. Werness, Arnold J. Levine, Peter M. Howley · Science · 1990 · 2.6K citations

Cervical Cancer, Human Papillomavirus Vaccines, Dna Tumor Virus +14

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

Suzanne J. Baker, Eric R. Fearon, Janice Nigro et al. · Science · 1989 · 2.1K citations

Tumor Biology, Oncogenic Agent, Medicine +13

The p53 proto-oncogene can act as a suppressor of transformation

Cathy A. Finlay, Philip W. Hinds, Arnold J. Levine · Cell · 1989 · 2K citations

Cell Regulation, Oncogenic Agent, P53 Proto-oncogene +6