Human topoisomerase I poisoning: docking protoberberines into a structure-based binding site model

The Protein Data Bank

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Biological Database, Biochemistry, Structural Bioinformatics +12

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.3K citations · Full text

Chromatin, Genome Instability, Dna Damage +12

Further development and validation of empirical scoring functions for structure-based binding affinity prediction

Renxiao Wang, Luhua Lai, Shaomeng Wang · Journal of Computer-Aided Molecular Design · 2002 · 1.2K citations · Full text

Systematic analysis of structural data as a research technique in organic chemistry

Frank H. Allen, Olga Kennard, Robin Taylor · Accounts of Chemical Research · 1983 · 1K citations

Engineering, Databases, Altmetric Attention Score +20

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Matthew R. Redinbo, Lance Stewart, Peter Kühn et al. · Science · 1998 · 874 citations