Arylcyanoacrylamides as inhibitors of the Dengue and West Nile virus proteases

Amino Acid Promoted CuI-Catalyzed C−N Bond Formation between Aryl Halides and Amines or N-Containing Heterocycles

Hui Zhang, Qian Cai, Dawei Ma · The Journal of Organic Chemistry · 2005 · 640 citations

Natural Sciences, Chemistry, Catalysis +12

1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(<i>S</i>)-pyrrolidine:  A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties

Edwin B. Villhauer, J. A. Brinkman, Goli B. Naderi et al. · Journal of Medicinal Chemistry · 2003 · 613 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus

P. Erbel, Nikolaus Schiering, A. D’Arcy et al. · Nature Structural & Molecular Biology · 2006 · 575 citations

Life Sciences, Infectious Diseases, Molecular Biology +16

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

Emanuele Perola · Journal of Medicinal Chemistry · 2010 · 191 citations

Pharmacy, Medicinal Chemistry, Drug Design +16

Peptide inhibitors of dengue virus NS3 protease. Part 1: Warhead

Zheng Yin, Sejal Patel, Weiling Wang et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 157 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +14