Concepedia

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

Olga A. Sedelnikova, Izumi Horikawa, Drazen B. Zimonjic, Nicholas C. Popescu, William M. Bonner, J. Carl Barrett

Nature Cell Biology · 2004 · 778 citations · 11 references

DOI

Concepts

References

11

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.4K citations · Full text

, , +15

A DNA damage checkpoint response in telomere-initiated senescence

Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature · 2003 · 2.8K citations

, , +14

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

Emmy P. Rogakou, Chye Boon, Christophe E. Redon et al. · The Journal of Cell Biology · 1999 · 2.4K citations · Full text

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

Tanya T. Paull, Emmy P. Rogakou, Vikky Yamazaki et al. · Current Biology · 2000 · 2.1K citations · Full text

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DNA Damage Foci at Dysfunctional Telomeres

Hiroyuki Takai, Agata Smogorzewska, Titia de Lange · Current Biology · 2003 · 1.4K citations · Full text

, , +14