Cucurbitacin-I, a natural cell-permeable triterpenoid isolated from Cucurbitaceae, exerts potent anticancer effect in colon cancer

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.

Michelle A. Blaskovich, Jiazhi Sun, Alan Cantor et al. · PubMed · 2003 · 569 citations

Medicine, Oncology, Pharmacology +15

Cell-Cycle Arrest at G2/M and Growth Inhibition by Apigenin in Human Colon Carcinoma Cell Lines

Weiqun Wang, Laura J. Heideman, Chilly S. Chung et al. · Molecular Carcinogenesis · 2000 · 269 citations

Medicine, Oncology, Pharmacology +17

Cucurbitacin B Induces Apoptosis by Inhibition of the <i>JAK/STAT</i> Pathway and Potentiates Antiproliferative Effects of Gemcitabine on Pancreatic Cancer Cells

Nils H. Thoennissen, Gabriela B. Iwanski, Ngan Doan et al. · Cancer Research · 2009 · 233 citations

Medicine, Oncology, Pharmacology +15

Growth inhibitory activity of cucurbitacin glucosides isolated from Citrullus colocynthis on human breast cancer cells

Tehila Tannin-Spitz, Shlomo Grossman, Sara Dovrat et al. · Biochemical Pharmacology · 2006 · 215 citations

Medicine, Oncology, Pharmacology +7

Individual and Interactive Effects of Apigenin Analogs on G2/M Cell-Cycle Arrest in Human Colon Carcinoma Cell Lines

Weiqun Wang, Peter C. VanAlstyne, Kimberly A. Irons et al. · Nutrition and Cancer · 2004 · 140 citations

Medicine, Oncology, Pharmacology +14