Activation of ERK signaling and induction of colon cancer cell death by piperlongumine

Genetic Alterations during Colorectal-Tumor Development

Bert Vogelstein, Eric R. Fearon, Stanley R. Hamilton et al. · New England Journal of Medicine · 1988 · 6.7K citations

Tumor Biology, Somatic Variant, Tumor Heterogeneity +13

Production of large amounts of hydrogen peroxide by human tumor cells.

Ted P. Szatrowski, Carl Nathan · PubMed · 1991 · 2.5K citations

Redox Signaling, Tumor Biology, Human Tumor Cells +15

Mitogen-Activated Protein Kinases and Reactive Oxygen Species: How Can ROS Activate MAPK Pathways?

Yong Son, Yong-Kwan Cheong, Nam‐Ho Kim et al. · Journal of Signal Transduction · 2011 · 1.2K citations · Full text

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

Lakshmi Raj, Takao Ide, Aditi U. Gurkar et al. · Nature · 2011 · 1K citations

Tumor Biology, Drug Targeting, Selective Killing +12

Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon

Kevin M. Haigis, K Kendall, Yufang Wang et al. · Nature Genetics · 2008 · 587 citations · Full text

Differential Effects, Oncogenic Agent, Medicine +9