Concepedia

α-LNA, locked nucleic acid with α-d-configuration

Poul Nielsen, Jakob K. Dalskov

Chemical Communications · 2000 · 24 citations · 15 references

DOI

Concepts

Abstract

The bicyclic thymine monomer of α-LNA (αTL) was efficiently synthesised and used in the synthesis of α-LNA sequences: incorporation of single αTL-monomers in α-configured oligothymidylates destabilises the affinity towards both complementary DNA and RNA, whereas a fully modified α-LNA sequence displays a very efficient recognition of complementary RNA.

References

15

LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognition

Alexei A. Koshkin, Sanjay K. Singh, Poul Nielsen et al. · Tetrahedron · 1998 · 1K citations

, , +16

Stability and structural features of the duplexes containing nucleoside analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides

Satoshi Obika, Daishu Nanbu, Yoshiyuki Hari et al. · Tetrahedron Letters · 1998 · 693 citations

, , +16

LNA (Locked Nucleic Acid):  An RNA Mimic Forming Exceedingly Stable LNA:LNA Duplexes

Alexei A. Koshkin, Poul Nielsen, Michael Meldgaard et al. · Journal of the American Chemical Society · 1998 · 339 citations

, , +12

Synthesis of 3‘-<i>C</i>- and 4‘-<i>C</i>-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

Jesper Wengel · Accounts of Chemical Research · 1998 · 334 citations

, , +12

Chemical synthesis of DNA and DNA analogs

Marvin H. Caruthers · Accounts of Chemical Research · 1991 · 276 citations

, , +6