Adjuvantive effects of anti-4-1BB agonist Ab and 4-1BBL DNA for a HIV-1 Gag DNA vaccine: Different effects on cellular and humoral immunity

Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors

Ignacio Melero, Walter W. Shuford, S A Newby et al. · Nature Medicine · 1997 · 891 citations

Life Sciences, Immunology, Oncology +14

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

Pascal Schneider, Nils Holler, Jean-Luc Bodmer et al. · The Journal of Experimental Medicine · 1998 · 803 citations · Full text

Life Sciences, Cell Biology, Immunology +16

4-1BB Costimulatory Signals Preferentially Induce CD8+ T Cell Proliferation and Lead to the Amplification In Vivo of Cytotoxic T Cell Responses

Walter W. Shuford, Kerry Klussman, Douglas D. Tritchler et al. · The Journal of Experimental Medicine · 1997 · 792 citations · Full text

Life Sciences, Cell Biology, Immunology +17

4-1BB Ligand Induces Cell Division, Sustains Survival, and Enhances Effector Function of CD4 and CD8 T Cells with Similar Efficacy

Jennifer L. Cannons, Peggy Lau, Birinder Ghumman et al. · The Journal of Immunology · 2001 · 353 citations · Full text

Life Sciences, Cell Biology, Immunology +17

4-1BB-mediated immunotherapy of rheumatoid arthritis

Su K. Seo, Jae‐Hoon Choi, Young H. Kim et al. · Nature Medicine · 2004 · 320 citations

Life Sciences, Clinical Sciences, Immunology +14