A quantitative assessment of hERG liability as a function of lipophilicity

Applied logistic regression

Choice Reviews Online · 1990 · 35.7K citations

Public Health, Biostatistics, Clinical Epidemiology +15

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews · 1997 · 11.2K citations

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A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel

Michael C. Sanguinetti, Changan Jiang, Mark Curran et al. · Cell · 1995 · 2.4K citations · Full text

Medicine, Cardiology, Molecular Genetics +16

A Comparison of Physiochemical Property Profiles of Development and Marketed Oral Drugs

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Pharmacy, Pharmacokinetics, Pharmacology +17

New insights about HERG blockade obtained from protein modeling, potential energy mapping, and docking studies

Ramy Farid, Tyler Day, Richard A. Friesner et al. · Bioorganic & Medicinal Chemistry · 2006 · 504 citations

Life Sciences, Biochemistry, Pharmacology +17