Concepedia

Design and synthesis of protein–protein interaction mimics as Plasmodium falciparum cysteine protease, falcipain-2 inhibitors

Luca Rizzi, Srividhya Sundararaman, Katarina Cendic, Nadia Vaiana, Reshma Korde, Dipto Sinha, Asif Mohmmed, Pawan Malhotra, Sergio Romeo

European Journal of Medicinal Chemistry · 2011 · 21 citations · 15 references

DOI

Concepts

References

15

The maximal affinity of ligands

Irwin D. Kuntz, K. Chen, Kim A. Sharp et al. · Proceedings of the National Academy of Sciences · 1999 · 845 citations

, , +16

Ligand efficiency indices as guideposts for drug discovery

C ABADZAPATERO · Drug Discovery Today · 2005 · 523 citations

, , +14

The refined 2.4 A X‐ray crystal structure of recombinant human stefin B in complex with the cysteine proteinase papain: a novel type of proteinase inhibitor interaction.

Milton T. Stubbs, Bernd Laber, Wolfram Bode et al. · The EMBO Journal · 1990 · 493 citations · Full text

, , +10

Characterization of Native and Recombinant Falcipain-2, a Principal Trophozoite Cysteine Protease and Essential Hemoglobinase ofPlasmodium falciparum

Bhaskar R. Shenai, Puran Singh Sijwali, Ajay Singh et al. · Journal of Biological Chemistry · 2000 · 343 citations · Full text

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Ligand Binding Efficiency: Trends, Physical Basis, and Implications

Charles H. Reynolds, Brett A. Tounge, Scott D. Bembenek · Journal of Medicinal Chemistry · 2008 · 318 citations

, , +15