Towards the development of chromone-based MEK1/2 modulators

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Jeffrey F. Ohren, Huifen Chen, A.G. Pavlovsky et al. · Nature Structural & Molecular Biology · 2004 · 621 citations

Life Sciences, Biochemistry, Molecular Biology +9

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

David J. Robbins, E. Zhen, Hajime Owaki et al. · Journal of Biological Chemistry · 1993 · 504 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +14

Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors

Julián Carretero, Takeshi Shimamura, Klarisa Rikova et al. · Cancer Cell · 2010 · 260 citations · Full text

Medicine, Molecular Biology, Oncology +16

Discovery of a Highly Potent and Selective MEK Inhibitor: GSK1120212 (JTP-74057 DMSO Solvate)

Hiroyuki Abé, Shinichi Kikuchi, Kazuhide Hayakawa et al. · ACS Medicinal Chemistry Letters · 2011 · 193 citations

Medicine, Oncology, Pharmacology +13

Refinement and Evaluation of a Pharmacophore Model for Flavone Derivatives Binding to the Benzodiazepine Site of the GABA_A Receptor

Pia Kahnberg, Erik Lager, Celia Rosenberg et al. · Journal of Medicinal Chemistry · 2002 · 130 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17