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Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa

Folkert Reck, David E. Ehmann, Thomas J. Dougherty, Joseph Newman, Sussie Hopkins, Gregory G. Stone, Nikunj Agrawal, Paul J. Ciaccio, John McNulty, Herbert Barthlow,

Bioorganic & Medicinal Chemistry · 2014 · 25 citations · 31 references

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31

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

Travis T. Wager, Xinjun Hou, Patrick R. Verhoest et al. · ACS Chemical Neuroscience · 2010 · 1K citations

, , +17

Type IIA topoisomerase inhibition by a new class of antibacterial agents

B.D. Bax, Pan F. Chan, Drake S. Eggleston et al. · Nature · 2010 · 842 citations

, , +13

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

Rosemarie O’Shea, Heinz E. Moser · Journal of Medicinal Chemistry · 2008 · 683 citations

, , +15

Intramolecular Hydrogen Bonding in Medicinal Chemistry

Bernd Kuhn, Peter J. Mohr, Martin Ståhl · Journal of Medicinal Chemistry · 2010 · 568 citations

, , +15

Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT

Matt Bridgland-Taylor, Alee Hargreaves, Alison Easter et al. · Journal of Pharmacological and Toxicological Methods · 2006 · 150 citations

, , +9