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Structure–activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II

Pharmaceutical SciencePharmacological StudyIndazole PiperazineDrug DiscoveryMedicineRational Drug DesignPharmacological AgentPharmacotherapyChemistryStructure–activity RelationshipsPharmacologyPharmaceutical ChemistryPharmacodynamic Modeling