Concepedia

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

Kan Uchiyama, Makoto Nakamura, Takahiro Kubota, Tateki Yamane, Kiyotaka Fujise, Hisao Tajiri

Journal of Gastroenterology · 2009 · 66 citations · 27 references

DOI

Concepts

References

27

Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity.

Richard M. Weinshilboum, S. L. Sladek · PubMed · 1980 · 1.2K citations

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Clinical Evaluation of a New Antimetabolite, 6-Mercaptopurine, in the Treatment of Leukemia and Allied Diseases

Joseph H. Burchenal, M. Lois Murphy, Rose Ruth Ellison et al. · Blood · 1953 · 391 citations · Full text

, , +13

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase)

Anthony M. Marinaki, Azhar Ansari, John A. Duley et al. · Pharmacogenetics · 2004 · 322 citations

, , +14

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

Hung-Liang Tai, Eugene Y. Krynetski, Charles R. Yates et al. · PubMed · 1996 · 320 citations

, , +15

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency

Satoshi Sumi, Anthony M. Marinaki, Monica Arenas et al. · Human Genetics · 2002 · 268 citations

, , +13