Hung-Liang Tai

Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance

Charles R. Yates, Eugene Y. Krynetski, Thrina Loennechen et al. · Annals of Internal Medicine · 1997 · 763 citations

Life Sciences, Genetics, Pharmacology +13

Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians.

Hung-Liang Tai, Eugene Y. Krynetski, Charles R. Yates et al. · PubMed · 1996 · 320 citations

Life Sciences, Genetics, Molecular Genetics +15

Enhanced proteolysis of thiopurine <i>S</i> -methyltransferase (TPMT) encoded by mutant alleles in humans ( <i>TPMT</i> ∗ <i>3</i> <i>A</i> , <i>TPMT</i> ∗ <i>2</i> ): Mechanisms for the genetic polymorphism of TPMT activity

Hung-Liang Tai, Eugene Y. Krynetski, Erin G. Schuetz et al. · Proceedings of the National Academy of Sciences · 1997 · 262 citations · Full text

Life Sciences, Genetics, Molecular Genetics +12

Enhanced proteasomal degradation of mutant human thiopurine S-methyltransferase (TPMT) in mammalian cells

Hung-Liang Tai, Michael Y. Fessing, Eric J. Bonten et al. · Pharmacogenetics and Genomics · 1999 · 118 citations

Life Sciences, Genetics, Molecular Biology +15

Validation of Precision-Cut Liver Slices in Dynamic Organ Culture as anin VitroModel for Studying CYP1A1 and CYP1A2 Induction

Adam T. Drahushuk, Barbara P. McGarrigle, Hung-Liang Tai et al. · Toxicology and Applied Pharmacology · 1996 · 63 citations

Pharmacy, Pharmacokinetics, Toxicology +13