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Pharmacokinetics of the hypoxic cell cytotoxic agent tirapazamine and its major bioreductive metabolites in mice and humans: retrospective analysis of a pharmacokinetically guided dose-escalation strategy in a phase I trial

Pharmacological StudyMedicineDose-escalation StrategyRetrospective AnalysisToxicologyPharmacotherapyMajor Bioreductive MetabolitesPharmacologyPharmacokineticsPharmacodynamic Modeling