Dose Optimization

Dose Optimization is a pharmacological strategy within clinical pharmacology and antimicrobial stewardship that systematically adjusts drug dosage regimens to achieve the desired therapeutic outcome while minimizing toxicity and resistance development through the integration of population pharmacokinetics, theranostic approaches, and evidence-based policy frameworks.

4.3K

Publications

198.7K

Citations

21.8K

Authors

4.5K

Institutions

Publications per year

2017–2026

1.4K

Variants

Dose Optimization Policies

Parents

Antimicrobial StewardshipAntimicrobial Stewardship PolicyClinical PharmacologyPopulation PharmacokineticsTheranostics

Children

Aminoglycoside Dosing OptimizationAntibiotic Dose IndividualizationBody Surface Area - Based DosingBody Weight - Based DosingConcentration - Time Profile AnalysisCritical Care DosingGeriatric Dosing OptimizationMaintenance Dose OptimizationMinimum Inhibitory Concentration - Based DosingObesity Dosing Optimization

Publications

4.3K

Estimation of the Warfarin Dose with Clinical and Pharmacogenetic Data

Teri E. Klein · New England Journal of Medicine · 2009 · 1.6K citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

DALI: Defining Antibiotic Levels in Intensive Care Unit Patients: Are Current -Lactam Antibiotic Doses Sufficient for Critically Ill Patients?

Jason A. Roberts, Sanjoy K. Paul, Murat Akova et al. · Clinical Infectious Diseases · 2014 · 1.1K citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP)

Brian T. Tsuji, Jason M. Pogue, Alexandre Prehn Zavascki et al. · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · 2019 · 931 citations · Full text

Pharmacy, Infectious Diseases, Pharmacology +17

Anthracycline Dose Intensification in Acute Myeloid Leukemia

Hugo F. Fernández, Zhuoxin Sun, Xiaopan Yao et al. · New England Journal of Medicine · 2009 · 907 citations · Full text

Medicine, Oncology, Pharmacotherapy +13

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

Christoph Hiemke, Pierre Baumann, N. Bergemann et al. · Pharmacopsychiatry · 2011 · 865 citations · Full text

Medicine, Pharmacology, Psychiatry +16

1–5 of 4.3K

Authors

21.8K

JA
Jason A. Roberts
The University of Queensland, Australia
53 publications · 5.2K citations
32
h-index
JL
Jeffrey Lipman
The University of Queensland, Australia
34 publications · 4.1K citations
27
h-index
GL
George L. Drusano
Albany Medical Center Hospital, United States
27 publications · 3K citations
23
h-index
TG
Tawanda Gumbo
Baylor University Medical Center, United States
30 publications · 1.6K citations
23
h-index
DP
David P. Nicolau
Hartford Hospital, United States
32 publications · 2.1K citations
22
h-index

1–5 of 21.8K

Institutions

4.5K

1–8 of 4.5K

Venues

Antimicrobial Agents and Chemotherapy
AAC · 272 publications · 14.3K citations
59
h-index
PubMed
Repository · 236 publications · 8.6K citations
47
h-index
Journal of Antimicrobial Chemotherapy
JAC · 125 publications · 5.1K citations
39
h-index
Clinical Pharmacology & Therapeutics
CPT · 65 publications · 4.8K citations
38
h-index
Journal of Clinical Oncology
59 publications · 5.7K citations
37
h-index

1–5