Concepedia

Dose Escalation Evaluation

Dose Escalation Evaluation is a methodological framework within pharmacokinetic and pharmacodynamic analysis that systematically assesses the relationship between increasing drug doses and corresponding changes in exposure metrics to determine dose-proportionality during clinical development.

734

Publications

38.1K

Citations

6.8K

Authors

1.7K

Institutions

Publications per year

2017–2026

265

Parents

Publications

734

Rituximab Dose-Escalation Trial in Chronic Lymphocytic Leukemia

Susan O’Brien, Hagop M. Kantarjian, Deborah A. Thomas et al. · Journal of Clinical Oncology · 2001 · 588 citations

, , +17

Tumor-Infiltrating Lymphocytes Genetically Engineered with an Inducible Gene Encoding Interleukin-12 for the Immunotherapy of Metastatic Melanoma

Ling Zhang, Richard A. Morgan, Joal D. Beane et al. · Clinical Cancer Research · 2015 · 452 citations · Full text

, , +17

Phosphatidylinositol 3-Kinase α–Selective Inhibition With Alpelisib (BYL719) in <i>PIK3CA</i>-Altered Solid Tumors: Results From the First-in-Human Study

Dejan Juric, Jordi Rodón, Josep Tabernero et al. · Journal of Clinical Oncology · 2018 · 439 citations

, , +14

Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe

Sélidji Todagbé Agnandji, Angela Huttner, Madeleine E. Zinser et al. · New England Journal of Medicine · 2015 · 413 citations · Full text

, , +17

Pharmacokinetics and Safety of Voriconazole following Intravenous- to Oral-Dose Escalation Regimens

Lynn Purkins, Nolan Wood, Parviz Ghahramani et al. · Antimicrobial Agents and Chemotherapy · 2002 · 413 citations · Full text

, , +13

1–5 of 734

Authors

6.8K

  1. HA
    Howard A. Burris

    Sarah Cannon, United States

    27 publications · 2.3K citations

    19

    h-index

  2. PL
    Patricia LoRusso

    The Barbara Ann Karmanos Cancer Institute, United States

    20 publications · 1.2K citations

    17

    h-index

  3. JT
    Josep Tabernero

    Vall d'Hebron Hospital Universitari, Spain

    14 publications · 1K citations

    14

    h-index

  4. JR
    Jeffrey R. Infante

    Sarah Cannon, United States

    13 publications · 944 citations

    12

    h-index

  5. AW
    Anthony W. Tolcher

    South Texas Accelerated Research Therapeutics, United States

    12 publications · 771 citations

    12

    h-index

1–5 of 6.8K

Institutions

1.7K

  1. The University of Texas MD Anderson Cancer Center

    Houston, United States

    37 h-index

    224 publications

    24.4K citations

  2. Dana-Farber Cancer Institute

    Boston, United States

    32 h-index

    116 publications

    11.3K citations

  3. Sarah Cannon

    Nashville, United States

    28 h-index

    132 publications

    6.8K citations

  4. Memorial Sloan Kettering Cancer Center

    New York, United States

    27 h-index

    126 publications

    5.2K citations

  5. Massachusetts General Hospital

    Boston, United States

    21 h-index

    94 publications

    5K citations

  6. Cornell University

    Ithaca, United States

    20 h-index

    78 publications

    4.5K citations

  7. Tennessee Oncology

    Nashville, United States

    20 h-index

    66 publications

    3.9K citations

  8. Princess Margaret Cancer Centre

    Toronto, Canada

    19 h-index

    65 publications

    2.4K citations

1–8 of 1.7K

Venues

  1. Journal of Clinical Oncology

    159 publications · 8.2K citations

    44

    h-index

  2. Clinical Cancer Research

    46 publications · 4K citations

    34

    h-index

  3. PubMed

    Repository · 34 publications · 1.2K citations

    21

    h-index

  4. British Journal of Cancer

    BJC · 20 publications · 1K citations

    16

    h-index

  5. Blood

    18 publications · 668 citations

    15

    h-index

1–5