Structural Clues to Prion Replication

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +17

Mice devoid of PrP are resistant to scrapie

Hansruedi Büeler, Adriano Aguzzi, Andreas W. Sailer et al. · Cell · 1993 · 2.1K citations · Full text

Veterinary Medicine, Infectious Diseases, Pathobiology +8

Scrapie prion protein contains a phosphatidylinositol glycolipid

Neil Stahl · Cell · 1987 · 1.1K citations

Veterinary Medicine, Biochemistry, Molecular Biology +14

Scrapie prions aggregate to form amyloid-like birefringent rods

Stanley B. Prusiner, Michael P. McKinley, Karen A. Bowman et al. · Cell · 1983 · 1K citations

Life Sciences, Infectious Diseases, Molecular Biology +14

Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

Mark S. Palmer, Aidan J. Dryden, John T. Hughes et al. · Nature · 1991 · 897 citations

Life Sciences, Genetics, Neurology +13