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Structure-activity studies of rapamycin analogs: evidence that the C-7 methoxy group is part of the effector domain and positioned at the FKBP12-FRAP interface

Juan I. Luengo, Dennis S. Yamashita, Damien J. Dunnington, Leonard W. Rozamus, Hwa-Kwo Yen, Mary J. Bossard, Mark A. Levy, Annalisa T. Hand, Tonie Newman‐Tarr, Alison M. Badger,

Chemistry & Biology · 1995 · 41 citations · 22 references

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22

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Jun S. Liu, Jesse D. Farmer, Willam S. Lane et al. · Cell · 1991 · 4.1K citations

, , +8

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Eric J. Brown, Mark W. Albers, Tae Bum Shin et al. · Nature · 1994 · 2.1K citations

, , +11

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

David M. Sabatini, Hediye Erdjument‐Bromage, Mary Lui et al. · Cell · 1994 · 1.5K citations

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Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin

Gregory D. Van Duyne, Robert F. Standaert, P. Andrew Karplus et al. · Journal of Molecular Biology · 1993 · 1.2K citations

, , +14

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

Jeannette Kunz, Rubén Henríquez, Ulrich Schneider et al. · Cell · 1993 · 841 citations

, , +14