Concepedia

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses

Hideyuki Yanai, Tatsuma Ban, Zhichao Wang, Myoung Kwon Choi, Takeshi Kawamura, Hideo Negishi, Makoto Nakasato, Yan Lu, Sho Hangai, Ryuji Koshiba,

Nature · 2009 · 686 citations · 24 references

DOI

Concepts

References

24

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Paola Scaffidi, Tom Misteli, Marco E. Bianchi · Nature · 2002 · 4.2K citations

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The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

Mitsutoshi Yoneyama, Mika Kikuchi, Takashi Natsukawa et al. · Nature Immunology · 2004 · 3.9K citations

, , +16

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Hiroki Kato, Osamu Takeuchi, Shintaro Sato et al. · Nature · 2006 · 3.8K citations

, , +12

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

, , +10

5'-Triphosphate RNA Is the Ligand for RIG-I

Veit Hornung, Jana M. Ellegast, Sarah Kim-Hellmuth et al. · Science · 2006 · 2.4K citations

, , +17