Effect of prostacyclin (PGI2) on platelet adhesion to rabbit arterial subendothelium

An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation

Salvador Moncada, Ryszard J. Gryglewski, S Bunting et al. · Nature · 1976 · 3.6K citations

Medicine, Biochemistry, Pharmacology +16

Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation

Stuart Bunting, Salvador Moncada, John R. Vane et al. · Prostaglandins · 1976 · 955 citations

Medicine, Physiology, Signal Transduction +11

Homocystine-induced arteriosclerosis. The role of endothelial cell injury and platelet response in its genesis.

Laurence A. Harker, Russell Ross, S. J. Slichter et al. · Journal of Clinical Investigation · 1976 · 939 citations · Full text

Medicine, Pathobiology, Physiology +17

HUMAN ARTERIAL AND VENOUS TISSUES GENERATE PROSTACYCLIN (PROSTAGLANDIN X), A POTENT INHIBITOR OF PLATELET AGGREGATION

Salvador Moncada, E.A. Higgs, John R. Vane · The Lancet · 1977 · 887 citations

Medicine, Hematology, Pharmacology +13

Differential formation of prostacyclin (PGX or PGI2) by layers of the arterial wall. An explanation for the anti-thrombotic properties of vascular endothelium

Salvador Moncada, A.G. Herman, E.A. Higgs et al. · Thrombosis Research · 1977 · 684 citations

Medicine, Cell Biology, Pharmacology +14