Activation of G-Proteins by Morphine and Codeine Congeners: Insights to the Relevance of O- and N-Demethylated Metabolites at μ- and δ-Opioid Receptors

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Hans W. D. Matthes, Rafaël Maldonado, Frédéric Simonin et al. · Nature · 1996 · 1.7K citations

Medicine, Neuroscience, Pharmacology +17

Opiate receptor knockout mice define μ receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Ichiro Sora, Nobuyuki Takahashi, Masahiko Funada et al. · Proceedings of the National Academy of Sciences · 1997 · 528 citations

Nursing, Pharmacology, Neuropharmacology +16

Light microscopic localization of brain opiate receptors: a general autoradiographic method which preserves tissue quality

Miles Herkenham, CB Pert · Journal of Neuroscience · 1982 · 467 citations · Full text

Life Sciences, Neurobiology, Neuroscience +8

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

John R. Traynor, Stefan R. Nahorski · Molecular Pharmacology · 1995 · 462 citations

Life Sciences, Biochemistry, Pharmacology +17

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.

Laura J. Sim, Dana E. Selley, Steven R. Childers · Proceedings of the National Academy of Sciences · 1995 · 456 citations · Full text

Life Sciences, Neuroscience, Pharmacology +16