PMS777, a New Cholinesterase Inhibitor with Anti-Platelet Activated Factor Activity, Regulates Amyloid Precursor Protein Processing In Vitro

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors

Roger M. Nitsch, Barbara E. Slack, Richard J. Wurtman et al. · Science · 1992 · 897 citations

Amyloid Deposits, Alzheimer's Disease, Medicine +15

Identification of the major Aβ1–42-degrading catabolic pathway in brain parenchyma: Suppression leads to biochemical and pathological deposition

Nobuhisa Iwata, Satoshi Tsubuki, Yoshie Takaki et al. · Nature Medicine · 2000 · 856 citations

Neurodegenerative Diseases, Synaptic Signaling, Degenerative Pathology +9

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

Steven L. Roberds · Human Molecular Genetics · 2001 · 703 citations

Bace Knockout Mice, Neurochemical Biomarkers, Disease Therapeutics +20

A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model

Rolf Postina, Anja Schroeder, Ilse Dewachter et al. · Journal of Clinical Investigation · 2004 · 619 citations

Inactive Adam10, Molecular Biology, Neurochemical Biomarkers +16