Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses

Stool Form Scale as a Useful Guide to Intestinal Transit Time

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An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking

Pierre Paré, Simon Ferrazzi, Wade Thompson et al. · The American Journal of Gastroenterology · 2001 · 440 citations

Medicine, Community Health, Health Sciences +14

Two Randomized Trials of Linaclotide for Chronic Constipation

Anthony Lembo, Harvey Schneier, Steven J. Shiff et al. · New England Journal of Medicine · 2011 · 372 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +17

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

Robert Busby, Alexander P. Bryant, Wilmin Bartolini et al. · European Journal of Pharmacology · 2010 · 248 citations

Life Sciences, Pharmacology, Physiology +13

Abnormal sensitivity to duodenal lipid infusion in patients with functional dyspepsia

Roberta Barbera, Christine Feinle, N W Read · European Journal of Gastroenterology & Hepatology · 1995 · 128 citations

Medicine, Nutrition, Physiology +14