Evaluation of risk factors for the development of nephropathy in patients with IDDM: insertion/deletion angiotensin converting enzyme gene polymorphism, hypertension and metabolic control

An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels.

Brigitte Rigat, C. Hübert, F Alhenc‐Gelas et al. · Journal of Clinical Investigation · 1990 · 3.8K citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction

François Cambien, Odette Poirier, Laure Lecerf et al. · Nature · 1992 · 1.9K citations

Medicine, Genetics, Molecular Genetics +14

Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels.

Laurence Tiret, Brigitte Rigat, C Breda et al. · PubMed · 1992 · 1.2K citations

Medicine, Genetics, Molecular Genetics +6

A Prospective Evaluation of an Angiotensin-Converting–Enzyme Gene Polymorphism and the Risk of Ischemic Heart Disease

Klaus Lindpaintner, Marc A. Pfeffer, Reinhold Kreutz et al. · New England Journal of Medicine · 1995 · 910 citations · Full text

Life Sciences, Cardiology, Genetics +11

Association between a Deletion Polymorphism of the Angiotensin-Converting-Enzyme Gene and Left Ventricular Hypertrophy

Heribert Schunkert, Hans‐Werner Hense, Stephan Holmer et al. · New England Journal of Medicine · 1994 · 747 citations · Full text

Medicine, Cardiology, Genetics +12