Concepedia

Enzyme Polymorphism Effects

Enzyme Polymorphism Effects is a pharmacogenetic phenomenon in phase II metabolism wherein interindividual genetic variations in enzyme-coding genes result in altered enzymatic activity, thereby affecting the biotransformation efficiency and pharmacokinetic profile of xenobiotics.

399

Publications

19.5K

Citations

2K

Authors

652

Institutions

Publications per year

2017–2026

19

Parents

Publications

399

A Second Genetic Polymorphism in Methylenetetrahydrofolate Reductase (MTHFR) Associated with Decreased Enzyme Activity

Ilan Weisberg, Pamela V. Tran, Benedicte Christensen et al. · Molecular Genetics and Metabolism · 1998 · 1.3K citations

, , +11

The effect of the human serum paraoxonase polymorphism is reversed with diazoxon, soman and sarin

Holly Davies, Rebecca J. Richter, Matthew Keifer et al. · Nature Genetics · 1996 · 598 citations

, , +5

Enzyme polymorphism in plant populations

A. H. D. Brown · Theoretical Population Biology · 1979 · 590 citations

, , +9

Relationships Between Angiotensin I Converting Enzyme Gene Polymorphism, Plasma Levels, and Diabetic Retinal and Renal Complications

Michel Marre, Pauline Bernadet, Yves Gallois et al. · Diabetes · 1994 · 366 citations

, , +15

Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization.

Saime Aksoy, C. L. Szumlanski, Richard M. Weinshilboum · Journal of Biological Chemistry · 1994 · 295 citations · Full text

, , +13

1–5 of 399

Authors

2K

  1. IT
    Ikiko Tsuritani

    Kanazawa Medical University, Japan

    4 publications · 170 citations

    4

    h-index

  2. GB
    George B. Johnson

    Washington University in St. Louis, United States

    4 publications · 190 citations

    4

    h-index

  3. FC
    François Cambien

    Inserm, France

    3 publications · 484 citations

    3

    h-index

  4. FS
    Fang Sun

    Columbia University, United States

    3 publications · 129 citations

    3

    h-index

  5. RM
    Richard M. Weinshilboum

    Mayo Clinic, United States

    3 publications · 630 citations

    3

    h-index

1–5 of 2K

Institutions

652

  1. Inserm

    Paris, France

    8 h-index

    27 publications

    2.7K citations

  2. Harvard University

    Cambridge, United States

    6 h-index

    15 publications

    671 citations

  3. Seoul National University

    Seoul, South Korea

    5 h-index

    24 publications

    542 citations

  4. Tri-Service General Hospital

    Taipei, Taiwan

    5 h-index

    9 publications

    217 citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    15 publications

    751 citations

  6. Kanazawa Medical University

    Kanazawa, Japan

    5 h-index

    18 publications

    731 citations

  7. University College London

    London, United Kingdom

    5 h-index

    12 publications

    1.1K citations

  8. University of Turin

    Turin, Italy

    4 h-index

    23 publications

    596 citations

1–8 of 652

Venues

  1. PubMed

    Repository · 31 publications · 1.2K citations

    19

    h-index

  2. Biochemical Genetics

    10 publications · 262 citations

    10

    h-index

  3. American Journal of Hypertension

    AJH · 9 publications · 330 citations

    9

    h-index

  4. Human Genetics

    9 publications · 402 citations

    9

    h-index

  5. Journal of Hypertension

    7 publications · 388 citations

    7

    h-index

1–5