Small · 2009 · 108 citations · 16 references
PharmacyBioengineeringBiotechnologyAntibody EngineeringDrug DesignPolymer ChemistryNanomedicineNanoparticle DesignNanoparticle FormulationsPeptide ChemistryPolymeric NanomaterialsPolymeric NanoparticlesAntibody-mediated Toxin NeutralizationBinding CapacityBinding Capacity OptimizationNanobody EngineeringPeptide NanoparticlesPolymer NanoparticlesPolymeric Nanoparticle SynthesisProtein-based Nanoparticles
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
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Tommy Cedervall, Iseult Lynch, Stina Lindman et al. · Proceedings of the National Academy of Sciences · 2007 · 3.2K citations · Full text
Detailed Identification of Plasma Proteins Adsorbed on Copolymer Nanoparticles
Tommy Cedervall, Iseult Lynch, Martina Foy et al. · Angewandte Chemie · 2007 · 655 citations