Concepedia

Nanobody Engineering

Nanobody Engineering is a protein engineering methodology that involves the rational design and optimization of nanobodies—single-domain antibodies derived from heavy-chain-only immunoglobulins—for enhanced binding affinity, stability, and therapeutic functionality within the context of protein-protein interaction modulation and therapeutic protein development.

343

Publications

18.7K

Citations

2.4K

Authors

683

Institutions

Publications per year

2017–2026

265

Parents

Publications

343

A general protocol for the generation of Nanobodies for structural biology

Els Pardon, Toon Laeremans, Sarah Triest et al. · Nature Protocols · 2014 · 812 citations

, , +7

The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications

Hansjörg Götzke, Markus Kilisch, Markel Martínez‐Carranza et al. · Nature Communications · 2019 · 679 citations · Full text

, , +15

Modulation of protein properties in living cells using nanobodies

Axel Kirchhofer, Jonas Helma, Katrin Schmidthals et al. · Nature Structural & Molecular Biology · 2009 · 637 citations

, , +8

General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold

Cécile Vincke, Remy Loris, Dirk Saerens et al. · Journal of Biological Chemistry · 2008 · 584 citations · Full text

, , +17

Camelid immunoglobulins and nanobody technology

Serge Muyldermans, Toya Nath Baral, V. Cortez Retamozzo et al. · Veterinary Immunology and Immunopathology · 2008 · 539 citations · Full text

, , +14

1–5 of 343

Authors

2.4K

  1. SM
    Serge Muyldermans

    Vrije Universiteit Brussel, Belgium

    20 publications · 3.8K citations

    17

    h-index

  2. BD
    Bruce D. Hammock

    University of California, Davis, United States

    8 publications · 311 citations

    10

    h-index

  3. MB
    Mahdi Behdani

    Pasteur Institute of Iran, Iran

    8 publications · 251 citations

    8

    h-index

  4. CV
    Cécile Vincke

    Vrije Universiteit Brussel, Belgium

    7 publications · 1.2K citations

    8

    h-index

  5. ND
    Nick Devoogdt

    Vrije Universiteit Brussel, Belgium

    7 publications · 711 citations

    8

    h-index

1–5 of 2.4K

Institutions

683

  1. Vrije Universiteit Brussel

    Brussels, Belgium

    21 h-index

    105 publications

    22.2K citations

  2. Harvard University

    Cambridge, United States

    14 h-index

    96 publications

    7K citations

  3. Howard Hughes Medical Institute

    Chevy Chase, United States

    12 h-index

    39 publications

    9.8K citations

  4. University of California, Davis

    Davis, United States

    11 h-index

    19 publications

    640 citations

  5. Chinese Academy of Sciences

    Beijing, China

    11 h-index

    52 publications

    2.8K citations

  6. University of Chinese Academy of Sciences

    Beijing, China

    11 h-index

    28 publications

    1.3K citations

  7. Pasteur Institute of Iran

    Tehran, Iran

    11 h-index

    44 publications

    1.7K citations

  8. Peking University

    Beijing, China

    9 h-index

    38 publications

    3.4K citations

1–8 of 683

Venues

  1. Scientific Reports

    13 publications · 945 citations

    14

    h-index

  2. Frontiers in Immunology

    12 publications · 316 citations

    13

    h-index

  3. bioRxiv (Cold Spring Harbor Laboratory)

    Repository · 11 publications · 197 citations

    10

    h-index

  4. Nature Communications

    9 publications · 1.4K citations

    9

    h-index

  5. Proceedings of the National Academy of Sciences

    PNAS · 8 publications · 286 citations

    8

    h-index

1–5