Design and synthesis of phthalimide-type histone deacetylase inhibitors

Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

Michael S. Finnin, Jill R. Donigian, Alona Cohen et al. · Nature · 1999 · 1.7K citations

Histone Modifications, Chromatin, Chromatin Structure +11

FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases.

Ryohei Furumai, Akihisa Matsuyama, Nobuyuki Kobashi et al. · PubMed · 2002 · 744 citations

Reductive Stress, Disulfide Bond, Biochemistry +15

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

Alessandro Vannini, Cinzia Volpari, Gessica Filocamo et al. · Proceedings of the National Academy of Sciences · 2004 · 620 citations · Full text

Histone Modifications, Histone Deacetylases, Crystal Structure +17

Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin

Ryohei Furumai, Yasuhiko Komatsu, Norikazu Nishino et al. · Proceedings of the National Academy of Sciences · 2000 · 410 citations · Full text

Hdac6 Inhibition, Bioorganic Chemistry, Aldo-keto Reductase +20

Inhibition of histone deacetylases: a new strategy to target epigenetic modifications for anticancer treatment.

Weidle Uh, Allie H. Grossmann · PubMed · 2000 · 129 citations

Histone Modifications, Histone Deacetylases, Epigenetic Change +18