High-mobility group box 1 activates caspase-1 and promotes hepatocellular carcinoma invasiveness and metastases

Abstract

These results suggest that in hypoxic HCC cells, HMGB1 activates TLR4- and RAGE-signaling pathways to induce caspase-1 activation with the subsequent production of multiple inflammatory mediators, which, in turn, promote cancer invasion and metastasis.