Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford R. Jack, David S. Knopman, William J. Jagust, +5

The Lancet Neurology

Alzheimer's DiseaseDementiaBiomarkersVascular DementiaNeurochemical Biomarkers +8

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Dale Schenk, Robin Barbour, Whitney Dunn, +22

Nature

Neurodegenerative DiseasesAlzheimer's DiseaseImmunologyDegenerative PathologyProtein Misfolding +5

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini, +31

Nature

Alzheimer-type NeuropathologyNeurodegenerative DiseasesAlzheimer's DiseaseMolecular NeuroscienceTransgenic Mouse Models +10

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Frédérique Bard, Catherine Cannon, Robin Barbour, +20

Nature Medicine

Amyloid β-Peptide EnterNeurodegenerative DiseasesAlzheimer's DiseaseMedicineImmunology +11

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

Ronald B. DeMattos, Kelly R. Bales, David J. Cummins, +3

Proceedings of the National Academy of Sciences

ImmunologyNeurochemical BiomarkersNeuroinflammationAlzheimer's DiseaseBrain Aβ Burden +17

Divergent Immunoglobulin G Subclass Activity Through Selective Fc Receptor Binding

Falk Nimmerjahn, Jeffrey V. Ravetch

Science

ImmunologyImmunodominanceImmunologic MechanismAntigen ProcessingSubclass Dominance +14

Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

Robert M. Koffie, Melanie Meyer‐Luehmann, Tadafumi Hashimoto, +9

Proceedings of the National Academy of Sciences

Synaptic TransmissionAlzheimer's DiseaseSenile PlaquesSynapse LossProtein Misfolding +14

Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease

Victor L. Villemagne, Kerryn E. Pike, Gaël Chételat, +14

Annals of Neurology

11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study

Juha O. Rinne, David J. Brooks, Martin N. Rossor, +14

The Lancet Neurology

Neurodegenerative DiseasesAscending-dose StudyAlzheimer's Disease11C-pib Pet AssessmentBiomarkers +8

Amyloid precursor protein processing and Aβ ₄₂ deposition in a transgenic mouse model of Alzheimer disease

Kelly Johnson‐Wood, M. Lee, Ruth Motter, +11

Proceedings of the National Academy of Sciences

Transgenic Mouse ModelSocial SciencesAlzheimer's DiseaseDegenerative PathologyProtein Misfolding +15