A Plaque-Specific Antibody Clears Existing β-amyloid Plaques in Alzheimer's Disease Mice

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Clifford R. Jack, David S. Knopman, William J. Jagust et al. · The Lancet Neurology · 2009 · 4.8K citations · Full text

Life Sciences, Neurobiology, Neuroscience +16

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

Dale Schenk, Robin Barbour, Whitney Dunn et al. · Nature · 1999 · 3.2K citations

Life Sciences, Neurology, Neuroscience +14

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

Dora Games, David S. Adams, Ree Alessandrini et al. · Nature · 1995 · 2.5K citations

Life Sciences, Neurology, Neuroscience +16

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

Frédérique Bard, Catherine Cannon, Robin Barbour et al. · Nature Medicine · 2000 · 2K citations

Life Sciences, Neurology, Neuroscience +17

Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease

Ronald B. DeMattos, Kelly R. Bales, David J. Cummins et al. · Proceedings of the National Academy of Sciences · 2001 · 1.3K citations · Full text

Pharmacy, Neurobiology, Neuroscience +17