<i>N</i>→<i>S</i> Acyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives

Abstract

N-->S acyl-transfer-mediated synthesis of peptide thioesters utilizing an N-aminoacyl-N-sulfanylethylaminobenzoic acid derivative has been examined. The developed synthetic methodology for peptide thioesters is compatible with Fmoc solid-phase peptide synthesis (SPPS).