Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats

Ryoya Oku, Masamichi Satoh, Nobutaka Fujii, +3

Brain Research

Spinal Cord InjuryHealth SciencesMedicineMechanical NociceptionPhysiology +12

A Low-Molecular-Weight Inhibitor against the Chemokine Receptor CXCR4: A Strong Anti-HIV Peptide T140

Hirokazu Tamamura, Younong Xu, Toshio Hattori, +9

Biochemical and Biophysical Research Communications

Low-molecular-weight InhibitorMedicineHuman RetrovirusImmunologyAntiviral Response +7

HIV protease inhibitor nelfinavir inhibits replication of SARS-associated coronavirus

Norio Yamamoto, Rongge Yang, Yoshiyuki Yoshinaka, +10

Biochemical and Biophysical Research Communications

Sars-associated CoronavirusImmunologyAntiviral Drug DevelopmentAntiviral TherapyVirology +4

T140 analogs as CXCR4 antagonists identified as anti‐metastatic agents in the treatment of breast cancer

Hirokazu Tamamura, Akira Hori, Naoyuki Kanzaki, +6

FEBS Letters

Inhibitory ActivityT140 AnalogsBreast OncologyMedicinePharmacology +12

Identification of Cell Binding Sites in the Laminin α1 Chain Carboxyl-terminal Globular Domain by Systematic Screening of Synthetic Peptides

Motoyoshi Nomizu, Woo Ho Kim, Keizo Yamamura, +6

Journal of Biological Chemistry

Molecular‐Size Reduction of a Potent CXCR4‐Chemokine Antagonist Using Orthogonal Combination of Conformation‐ and Sequence‐Based Libraries

Nobutaka Fujii, Shinya Oishi, Kenichi Hiramatsu, +11

Angewandte Chemie International Edition

Peptide EngineeringMolecular BiologyPeptide SciencePeptide TherapeuticsMolecular Pharmacology +15

Chemical Synthesis of Biologically Active Monoglycosylated GM2‐Activator Protein Analogue Using <i>N</i>‐Sulfanylethylanilide Peptide

Kohei Sato, Akira Shigenaga, Keisuke Kitakaze, +4

Angewandte Chemie International Edition

Remodeling of gp41-C34 Peptide Leads to Highly Effective Inhibitors of the Fusion of HIV-1 with Target Cells We thank Dr. Terrence R. Burke, Jr., NCI, NIH, Frederick, MD 21702-1201, for proofreading the manuscript and providing useful comments. This research was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology, Japan, the Japan Society for the Promotion of Science, and the Japan Health Science Foundation.

Akira Otaka, Miki Nakamura, Daisuke Nameki, +8

Angewandte Chemie International Edition

Sc PeptidesPeptide EngineeringImmunologySix-helix Peptide BundleMolecular Biology +19

Preparation of fluoro- and hydroxy-4-(phosphonomethyl)-D,L-phenylalanine suitably protected for solid-phase synthesis of peptides containing hydrolytically stable analogs of O-phosphotyrosine

Terrence R. Burke, Mark S. Smyth, Motoyoshi Nomizu, +2

The Journal of Organic Chemistry

Stable AnalogsBioorganic ChemistrySolid-phase SynthesisBiochemistryDonut Icon +12

A highly stereoselective synthesis of (E)-alkene dipeptide isosteres via organocyanocopper-Lewis acid mediation reaction

Toshiro Ibuka, Hiromu Habashita, Akira Otaka, +4

The Journal of Organic Chemistry

Cross-coupling ReactionEngineeringAlkene Metathesis-Alkene Dipeptide IsosteresNatural Sciences +11