Cladribine (2-chloro-deoxyadenosine, CDA): an inhibitor of human B and T cell activation in vitro

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

S Seto, C J Carrera, Masaru Kubota et al. · Journal of Clinical Investigation · 1985 · 388 citations · Full text

Medicine, Biochemistry, Pharmacology +13

Specific toxicity of 2-chlorodeoxyadenosine toward resting and proliferating human lymphocytes

DA Carson, DB Wasson, Raymond Taetle et al. · Blood · 1983 · 273 citations · Full text

Pharmacy, Biochemistry, Toxicology +5

Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo.

D A Carson, D B Wasson, Jonathan Kaye et al. · Proceedings of the National Academy of Sciences · 1980 · 224 citations · Full text

Medicine, Oncology, Pharmacology +15

Interaction of 2-halogenated dATP analogs (F, Cl, and Br) with human DNA polymerases, DNA primase, and ribonucleotide reductase.

William B. Parker, Ashok R. Bapat, Jia-Xiang Shen et al. · Molecular Pharmacology · 1988 · 144 citations

Life Sciences, Biochemistry, Molecular Biology +17

Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy.

C J Carrera, Chihiro Terai, Martin Lotz et al. · Journal of Clinical Investigation · 1990 · 127 citations · Full text

Life Sciences, Immunology, Pharmacology +17