Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs

Alfred H. Schinkel, Jasper Smit, Olaf van Tellingen et al. · Cell · 1994 · 2.3K citations

Medicine, Pharmacokinetics, Pharmacology +14

Flavonoids: A class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse P-glycoprotein

Gwenaëlle Conseil, Helene Baubichon-Cortay, Guila Dayan et al. · Proceedings of the National Academy of Sciences · 1998 · 379 citations

Medicine, Biochemistry, Pharmacology +12

Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog1Note: Nucleotide sequence data reported in this paper have been submitted to the GenBank data base with the accession number AF 003908.1

Ming Xu, Marcelo Beltrão Molento, William J. Blackhall et al. · Molecular and Biochemical Parasitology · 1998 · 293 citations

Life Sciences, Biology, Genetics +15

Avermectins: novel insecticides, acaricides and nematicides from a soil microorganism

Irving Putter, JA Connell, Franz A. Preiser et al. · Cellular and Molecular Life Sciences · 1981 · 263 citations

Agriculture, Entomology, Soil Sciences +14

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

Elizabeth A. Dierks, Karen R. Stams, Heng‐Keang Lim et al. · PubMed · 2001 · 237 citations

Medicine, Pharmacokinetics, Pharmacology +16