Concepedia

Inhibition of Hsp90 Leads to Cell Cycle Arrest and Apoptosis in Human Malignant Pleural Mesothelioma

Junichi Okamoto, Iwao Mikami, Yuichi Tominaga, Kristopher Kuchenbecker, Yu‐Ching Lin, Dawn T. Bravo, Geneviève Clément, Adam Yagui‐Beltrán, M. Ray, Kiyoshi Koizumi,

Journal of Thoracic Oncology · 2008 · 59 citations · 42 references

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A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors

Adeela Kamal, Lia Thao, John Sensintaffar et al. · Nature · 2003 · 1.4K citations

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Structure of TPR Domain–Peptide Complexes

Clemens Scheufler, Achim Brinker, Gleb Bourenkov et al. · Cell · 2000 · 1.2K citations · Full text

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Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

John Brognard, Amy S. Clark, Yucheng Ni et al. · PubMed · 2001 · 892 citations

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Akt Forms an Intracellular Complex with Heat Shock Protein 90 (Hsp90) and Cdc37 and Is Destabilized by Inhibitors of Hsp90 Function

Andrea Basso, David B. Solit, Gabriela Chiosis et al. · Journal of Biological Chemistry · 2002 · 626 citations · Full text

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

James P. Grenert, W. Patrick Sullivan, Patrick Fadden et al. · Journal of Biological Chemistry · 1997 · 570 citations · Full text

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