Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

Kazumitsu Ueda, Carol Cardarelli, Michael M. Gottesman et al. · Proceedings of the National Academy of Sciences · 1987 · 1.1K citations · Full text

Medicine, Molecular Biology, Oncology +11

Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line

Huan Meng, Monty Liong, Tian Xia et al. · ACS Nano · 2010 · 895 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines

John R. Riordan, Kathryn L. Deuchars, Norbert Kartner et al. · Nature · 1985 · 841 citations

Medicine, Molecular Biology, Oncology +7

Co-delivery of drugs and DNA from cationic core–shell nanoparticles self-assembled from a biodegradable copolymer

Yong Wang, Shujun Gao, Wenhui Ye et al. · Nature Materials · 2006 · 655 citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +14

Co-Delivery of siRNA and An Anticancer Drug for Treatment of Multidrug-Resistant Cancer

Maha Saad, Olga B. Garbuzenko, Tamara Minko · Nanomedicine · 2008 · 367 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17