Allyl-, butyl- and phenylethyl-isothiocyanate activate Nrf2 in cultured fibroblasts

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Aldo-keto Reductase, Molecular Biology, Thiol Addition +19

Toxicity determined in vitro by morphological alterations and neutral red absorption

Ellen Borenfreund, James A. Puerner · Toxicology Letters · 1985 · 1.9K citations

Biochemistry, Medicine, Morphological Alterations +6

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

Nobunao Wakabayashi, Albena T. Dinkova‐Kostova, W. David Holtzclaw et al. · Proceedings of the National Academy of Sciences · 2004 · 959 citations · Full text

Molecular Biology, Redox Biology, Oxidant Stress +19