Molecular BioSystems · 2012 · 22 citations · 22 references
Life SciencesMedicinal ChemistryMolecular BiologyDrug DiscoveryMolecular VirologyVirologyAntiviral AgentsAntiviral PharmacologyAntiviral TherapyRna StructureViral Rna BiologyViral TranscriptionAminoglycoside AntibioticsAntiviral Structure-activity RelationshipsAntiviral TherapeuticsInfluenza Antiviral TherapyInfluenza TreatmentInfluenza Virus TranscriptionRibonucleotide ChemistryViral Rna Structure
Aminoglycosides bind to the influenza A virus promoter (vRNA) at submicromolar concentration. The complex structure between the vRNA and neomycin illustrates that binding of neomycin causes a conformational change which would affect further transcription processes. Thus, aminoglycosides represent lead compounds for the discovery of antiviral therapeutics against influenza A virus.
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Rational design of potent sialidase-based inhibitors of influenza virus replication
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Influenza virus M2 protein has ion channel activity
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