Engineered resistance to camptothecin and antifolates by retroviral coexpression of tyrosyl DNA phosphodiesterase-I and thymidylate synthase

Arrest of replication forks by drug-stabilized topoisomerase I-DNA cleavable complexes as a mechanism of cell killing by camptothecin.

Y H Hsiang, M G Lihou, Leroy F. Liu · PubMed · 1989 · 1K citations

Chromatin, Genome Instability, Fork Breakage +9

A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

Shujun Yang, Alex B. Burgin, Beth N. Huizenga et al. · Proceedings of the National Academy of Sciences · 1996 · 402 citations · Full text

Chromatin, Genome Instability, Biosynthesis +13

Yeast Gene for a Tyr-DNA Phosphodiesterase that Repairs Topoisomerase I Complexes

Jeffrey J. Pouliot, Kevin C. Yao, C A Robertson et al. · Science · 1999 · 379 citations · Full text

Fungal Cell Biology, Genetics, Tyr-dna Phosphodiesterase +19

DNA topoisomerase I-mediated DNA cleavage and cytotoxicity of camptothecin analogues.

Y H Hsiang, Leroy F. Liu, Monroe E. Wall et al. · PubMed · 1989 · 341 citations

Hematological Malignancy, Tumor Biology, Medicinal Chemistry +15

The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily

Heidrun Interthal, Jeffrey J. Pouliot, James J. Champoux · Proceedings of the National Academy of Sciences · 2001 · 284 citations · Full text

Proteinlipid Interaction, Protein Function, Signal Transduction +15