H. Trent Spencer

Cytokine-Mediated Disruption of Lymphocyte Trafficking, Hemopoiesis, and Induction of Lymphopenia, Anemia, and Thrombocytopenia in Anti-CD137-Treated Mice

Liguo Niu, Simona Strahotin, Becker Hewes et al. · The Journal of Immunology · 2007 · 171 citations · Full text

Life Sciences, Hematology, Immunology +17

Methotrexate-resistant Variants of Human Dihydrofolate Reductase with Substitutions of Leucine 22

William S. Lewis, Vivian Cody, Nikolai Galitsky et al. · Journal of Biological Chemistry · 1995 · 145 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk, Shuhua Wang, Kevin Z. Chen et al. · Blood · 2022 · 132 citations · Full text

Life Sciences, Oncology, Pharmacology +17

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

Philip M. Zakas, Harrison C. Brown, Kristopher A. Knight et al. · Nature Biotechnology · 2016 · 109 citations

Life Sciences, Bioinformatics, Pharmacology +14

Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists

Christopher T. Petersen, Mojibade Hassan, Anna B. Morris et al. · Blood Advances · 2018 · 106 citations · Full text

Medicine, Oncology, Pharmacology +15