Harrison C. Brown

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

Philip M. Zakas, Harrison C. Brown, Kristopher A. Knight et al. · Nature Biotechnology · 2016 · 107 citations · Full text

Protein Drugs, Drug Repositioning, Drug Target +13

Enhanced Biosynthesis of Coagulation Factor VIII through Diminished Engagement of the Unfolded Protein Response

Harrison C. Brown, Bagirath Gangadharan, Christopher B. Doering · Journal of Biological Chemistry · 2011 · 44 citations · Full text

Enhanced Biosynthesis, Immunology, Porcine Fviii Biosynthesis +21

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

Harrison C. Brown, J. Fraser Wright, Shangzhen Zhou et al. · Molecular Therapy — Methods & Clinical Development · 2014 · 41 citations · Full text

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

Alok Srivastava, Aby Abraham, Fouzia N. Aboobacker et al. · New England Journal of Medicine · 2024 · 41 citations · Full text

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A

Harrison C. Brown, Philip M. Zakas, Stephan George et al. · Molecular Therapy — Methods & Clinical Development · 2018 · 39 citations · Full text