Harrison C. Brown

Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction

Philip M. Zakas, Harrison C. Brown, Kristopher A. Knight et al. · Nature Biotechnology · 2016 · 109 citations

Life Sciences, Bioinformatics, Pharmacology +14

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

Alok Srivastava, Aby Abraham, Fouzia N. Aboobacker et al. · New England Journal of Medicine · 2024 · 50 citations · Full text

Medicine, Hematology, Molecular Medicine +17

Enhanced Biosynthesis of Coagulation Factor VIII through Diminished Engagement of the Unfolded Protein Response

Harrison C. Brown, Bagirath Gangadharan, Christopher B. Doering · Journal of Biological Chemistry · 2011 · 44 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Bioengineered coagulation factor VIII enables long-term correction of murine hemophilia A following liver-directed adeno-associated viral vector delivery

Harrison C. Brown, J. Fraser Wright, Shangzhen Zhou et al. · Molecular Therapy — Methods & Clinical Development · 2014 · 41 citations · Full text

Pharmacy, Biotechnology, Hematology +14

Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A

Harrison C. Brown, Philip M. Zakas, Stephan George et al. · Molecular Therapy — Methods & Clinical Development · 2018 · 41 citations · Full text

Life Sciences, Bioengineering, Biotechnology +15