Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies

Aging: A Theory Based on Free Radical and Radiation Chemistry

Denham Harman · Journal of Gerontology · 1956 · 8.5K citations

Natural Sciences, Chemistry, Aging +16

c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis

Zuoning Han, David L. Boyle, Lufen Chang et al. · Journal of Clinical Investigation · 2001 · 775 citations · Full text

Life Sciences, Immunology, Molecular Biology +13

Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

Holly Van Remmen, Yuji Ikeno, Michelle M. Hamilton et al. · Physiological Genomics · 2003 · 733 citations

Life Sciences, Genetics, Molecular Biology +15

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors

Sunyoung Lee, Shahla M. Jilani, Ganka Nikolova et al. · The Journal of Cell Biology · 2005 · 699 citations · Full text

Medicine, Cancer Biology, Oncology +17

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life

Sailaja Elchuri, Terry D. Oberley, Wenbo Qi et al. · Oncogene · 2004 · 665 citations

Pharmacy, Biochemistry, Toxicology +14