Telomerase-dependent oncolytic adenovirus for cancer treatment

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

Medicine, Cancer Biology, Oncology +14

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

Medicine, Oncology, Chemotherapy +8

Inhibition of telomerase limits the growth of human cancer cells

William C. Hahn, Sheila A. Stewart, Mary W. Brooks et al. · Nature Medicine · 1999 · 1K citations

Medicine, Cell Biology, Oncology +12

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise, Adam Sampson-Johannes, Angelica Williams et al. · Nature Medicine · 1997 · 947 citations

Medicine, Oncology, Pharmacology +13

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

Carla Heise, Terry Hermiston, Leisa Johnson et al. · Nature Medicine · 2000 · 585 citations

Medicine, Oncology, Pharmacology +12