David H. Kirn

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

Mutant Adenovirus, Adenovirus Mutant, Functional P53 +13

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

Intratumoral Onyx-015, Neck Cancer, Medicine +11

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise, Adam Sampson-Johannes, Angelica Williams et al. · Nature Medicine · 1997 · 944 citations

Tumor Biology, Cancer-associated Virus, Oncogenic Agent +10

An essential role for Rac in Ras transformation

Rongguo Qiu, Jing Chen, David H. Kirn et al. · Nature · 1995 · 884 citations

Computational Imaging, Inverse Problems, Ras Transformation +2

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer

Jeong Heo, Tony Reid, Leyo Ruo et al. · Nature Medicine · 2013 · 753 citations · Full text

Vaccination, Dose-finding Clinical Trial, Hepatology +12