An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams, +8

Science

Mutant AdenovirusAdenovirus MutantFunctional P53Mutant AdenovirusesMedicine +11

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly, +13

Nature Medicine

Intratumoral Onyx-015Neck CancerMedicinePathologyHead And Neck Cancer +9

ONYX-015, an E1B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents

Carla Heise, Adam Sampson-Johannes, Angelica Williams, +3

Nature Medicine

Tumor BiologyCancer-associated VirusOncogenic AgentMedicineTumor-specific Cytolysis +8

An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

Carla Heise, Terry Hermiston, Leisa Johnson, +5

Nature Medicine

Tumor BiologyMedicineAdenovirus E1a MutantImmunologyPathology +6

A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer.

Ian Ganly, David H. Kirn, Gail Eckhardt, +10

PubMed

Neck CancerImmunologyPathologyAdenovirus DnaTumor Biology +14

A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell Lines

Paul W. Hollenbach, Aaron Nguyen, Helen Brady, +7

PLoS ONE

Hepatic arterial infusion of a replication-selective oncolytic adenovirus (dl1520): phase II viral, immunologic, and clinical endpoints.

Tony Reid, E. Galanis, James L. Abbruzzese, +10

PubMed

Viral ReplicationReplication-selective Oncolytic AdenovirusImmunologyPathologyReplication-selective Oncolytic Adenoviruses +17

Safety and feasibility of injection with an E1B-55 kDa gene-deleted, replication-selective adenovirus (ONYX-015) into primary carcinomas of the pancreas: a phase I trial

Sean J. Mulvihill, Robert S. Warren, Alan P. Venook, +4

Gene Therapy

Replication-selective AdenovirusE1b-55 KdaPancreatic CancerPrimary CarcinomasMedicine +6

CHIR-258, a novel, multitargeted tyrosine kinase inhibitor for the potential treatment of t(4;14) multiple myeloma

Suzanne Trudel, Zhihua Li, Ellen Wei, +6

Blood

Intravenous administration of ONYX-015, a selectively replicating adenovirus, induces antitumoral efficacy.

Carla Heise, Alan M Williams, Shengli Xue, +2

PubMed

Tumor BiologyViral ReplicationIntravenous AdministrationOncogenic AgentMedicine +13