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N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics

Paul Bamborough, Richard Angell, Inder Bhamra, David Brown, James A. Bull, J.A. Christopher, Lynsey Fazal, Ilaria Giordano, Lucy Hind, Vipulkumar K. Patel,

Bioorganic & Medicinal Chemistry Letters · 2007 · 49 citations · 13 references

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Development and validation of a genetic algorithm for flexible docking 1 1Edited by F. E. Cohen

Gareth Jones, Peter Willett, Robert C. Glen et al. · Journal of Molecular Biology · 1997 · 6.7K citations

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Manuscript Preparation

Obesity Surgery · 1997 · 3.9K citations

Profound block in thymocyte development in mice lacking p56lck

Thierry Jo Molina, Kenji Kishihara, David P. Siderovski et al. · Nature · 1992 · 966 citations

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SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Jennifer M. Golas, Kim Arndt, Carlo Etienne et al. · PubMed · 2003 · 414 citations

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<i>N</i>-(5-Chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy]-5- (tetrahydro-2<i>H</i>-pyran-4-yloxy)quinazolin-4-amine, a Novel, Highly Selective, Orally Available, Dual-Specific c-Src/Abl Kinase Inhibitor

Laurent Hennequin, J M Allen, J. Breed et al. · Journal of Medicinal Chemistry · 2006 · 367 citations · Full text

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