Ilaria Giordano

Type IIA topoisomerase inhibition by a new class of antibacterial agents

B.D. Bax, Pan F. Chan, Drake S. Eggleston et al. · Nature · 2010 · 842 citations

Medicine, Medicinal Chemistry, Pharmacology +13

Discovery of a Potent and Specific <i>M. tuberculosis</i> Leucyl-tRNA Synthetase Inhibitor: (<i>S</i>)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[<i>c</i>][1,2]oxaborol-1(3<i>H</i>)-ol (GSK656)

Xianfeng Li, Vincent Hernandez, Fernando Rock et al. · Journal of Medicinal Chemistry · 2017 · 162 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Timothy J. Miles, Alan J. Hennessy, B.D. Bax et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 64 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases

Timothy J. Miles, Christopher W. Barfoot, Gerald Brooks et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 53 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: Indazoles as phenol isosteres with improved pharmacokinetics

Paul Bamborough, Richard Angell, Inder Bhamra et al. · Bioorganic & Medicinal Chemistry Letters · 2007 · 49 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +8