Timothy J. Miles

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Alexandre Wohlkönig, Pan F. Chan, Andrew Fosberry et al. · Nature Structural & Molecular Biology · 2010 · 305 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition

Susan Wyllie, Stephen Brand, Michael G. Thomas et al. · Proceedings of the National Academy of Sciences · 2019 · 173 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis

Susan Wyllie, Michael G. Thomas, Stephen Patterson et al. · Nature · 2018 · 145 citations · Full text

Veterinary Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis of highly-functionalised pyridines via hetero-Diels–Alder methodology: reaction of 3-siloxy-1-aza-1,3-butadienes with electron deficient acetylenes

Matthew D. Fletcher, Timothy E. Hurst, Timothy J. Miles et al. · Tetrahedron · 2006 · 67 citations

Natural Sciences, Chemistry, Organic Chemistry +7

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Timothy J. Miles, Alan J. Hennessy, B.D. Bax et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 64 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +10